의과대학 - 의과대학

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관심분야

살모넬라균 면역세포 내 생존 메커니즘 연구
살모넬라균 병원성 단백질 발현 조절 연구

학력

  • (Ph.D.) 서울대학교 농생명공학부, 2002년

약력/경력

  • 2002년-2006년, Washington University School of Medicine, Research Associate
  • 2006년-2007년, 서울대학교 농업생물신소재연구센터, 연구조교수
  • 2007년-2011년, 성균관대학교 의과대학 의학과, 조교수
  • 2011년-현재, 성균관대학교 의과대학 의학과, 부교수

학술지 논문

  • (2024)  Conversion to colistin susceptibility by tigecycline exposure in colistin-resistant Klebsiella pneumoniae and its implications to combination therapy.  INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS.  63,  1
  • (2020)  Change of Hypermucoviscosity in the Development of Tigecycline Resistance in Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strains.  MICROORGANISMS.  8,  10
  • (2020)  Comparison of Fitness Cost and Virulence in Chromosome- and Plasmid-Mediated Colistin-Resistant Escherichia coli.  FRONTIERS IN MICROBIOLOGY.  11,  -
  • (2020)  Co-introduction of plasmids harbouring the carbapenemase genes, bla(NDM-1) and bla(OXA-232), increases fitness and virulence of bacterial host.  JOURNAL OF BIOMEDICAL SCIENCE.  27,  1
  • (2019)  The mgtCBR mRNA Leader Secures Growth of Salmonella in Both Host and Non-host Environments.  FRONTIERS IN MICROBIOLOGY.  10,  -
  • (2019)  Lytic transglycosylase contributes to the survival of lipooligosaccharide-deficient, colistin-dependent Acinetobacter baumannii.  CLINICAL MICROBIOLOGY AND INFECTION.  25,  9
  • (2018)  ATP reduction by MgtC and Mg2+ homeostasis by MgtA and MgtB enables Salmonella to accumulate RpoS upon low cytoplasmic Mg2+ stress.  MOLECULAR MICROBIOLOGY.  110,  2
  • (2017)  Peroxiredoxin-6 Negatively Regulates Bactericidal Activity and NF-kappa B Activity by Interrupting TRAF6-ECSIT Complex.  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.  7,  94
  • (2016)  tRNA(Pro)-mediated downregulation of elongation factor P is required for mgtCBR expression during Salmonella infection.  MOLECULAR MICROBIOLOGY.  102,  2
  • (2016)  Fumarate-Mediated Persistence of Escherichia coli against Antibiotics.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.  60,  4
  • (2016)  CRISPR/Cas9-Mediated Re-Sensitization of Antibiotic-Resistant Escherichia coli Harboring Extended-Spectrum beta-Lactamases.  JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY.  26,  2
  • (2015)  Lon-Mediated Proteolysis of the FeoC Protein Prevents Salmonella enterica from Accumulating the Fe(II) Transporter FeoB under High-Oxygen Conditions.  JOURNAL OF BACTERIOLOGY.  197,  1
  • (2014)  Development of colistin resistance in pmrA-, phoP-, parR- and cprR-inactivated mutants of Pseudomonas aeruginosa.  JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY.  69,  11
  • (2014)  The Iron-Sensing Fur Regulator Controls Expression Timing and Levels of Salmonella Pathogenicity Island 2 Genes in the Course of Environmental Acidification.  INFECTION AND IMMUNITY.  82,  6
  • (2014)  Structural insights into the molecular mechanism of Escherichia coli SdiA, a quorum-sensing receptor.  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY.  70,  3
  • (2013)  The FeoC Protein Leads to High Cellular Levels of the Fe(II) Transporter FeoB by Preventing FtsH Protease Regulation of FeoB in Salmonella enterica.  JOURNAL OF BACTERIOLOGY.  195,  15
  • (2012)  Expression of STM4467-Encoded Arginine Deiminase Controlled by the STM4463 Regulator Contributes to Salmonella enterica Serovar Typhimurium Virulence.  INFECTION AND IMMUNITY.  80,  12
  • (2012)  The FeoA protein is necessary for the FeoB transporter to import ferrous iron.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.  423,  4
  • (2012)  LsrR-Mediated Quorum Sensing Controls Invasiveness of Salmonella typhimurium by Regulating SPI-1 and Flagella Genes.  PLOS ONE.  7,  5
  • (2012)  Intrinsic Negative Feedback Governs Activation Surge in Two-Component Regulatory Systems.  MOLECULAR CELL.  45,  3

수상/공훈

  • 2010년-2015년, 한국미생물학회 국제학술지 Journla of Microbiology 편집위원
  • 2012년, 한국미생물학회 KRIBB 학술상 수상

학술회의논문

  • (2015)  The Iron-Sensing Fur Regulator Controls Expression Timing and Levels of Salmonella Pathogenicity Island 2 Genes.  KMB 2015 42nd Annual Meeting & International Symposium.  대한민국
  • (2008)  Regulation of iron-responsive genes by the Salmonella RstA/RstB two-component system.  International Meeting of the Federation of Korean Microbilogical Societies.  대한민국
  • (2007)  Effect of the RstA/RstB two-component system on Salmonella virulence and identification of its regulated genes.  International Meeting of the Federation of Korean Microbiological Societies.  대한민국
  • (2007)  Regulation of Salmonella Virulence by the PhoP/PhoQ Two-Component System.  International Meeting of the Federation of Korean Microbiological Societies.  대한민국
  • (2007)  Regulation of Salmonella virulence by two-component signal transduction systems.  대한미생물학회 하계 네트워킹 심포지움.  대한민국